|
Carnosine
Eye drops
Preserving Your Eyesight
Young eyes contain high concentrations of natural antioxidants that protect against cataract, macular degeneration and other ocular disorders. In the aged eye, synthesis of the antioxidant glutathione is reduced, resulting in excessive free radical damage.
Antioxidant supplements have been shown to help protect against senile eye disorders. [1] Unfortunately, aging diminishes circulation to the eye, [2] thereby reducing the efficacy of orally ingested supplements.
to order
The findings from a recent study conclude: [3]
"A need exists for development of therapeutic agents to slow age-related loss of antioxidant activity in the nucleus of the human lens to delay the onset of cataract."
Free radicals for the most part cause cataracts and other senile eye disorders. Oxidative stress is also a contributing factor in the development of macular degeneration. [4]
According to a recent report, [5] "nutritional intervention to enhance the glutathione antioxidant capacity…may provide an effective way to prevent or treat age-related macular degeneration." Even glaucoma has been linked with reduced blood flow and increased levels of damaging free radicals. [6]
Another problem with aging eyes is protein degradation and the formation of advanced glycation end products. Aged eyes fail to break down and remove old proteins linked by sugar molecules, which results in the accumulation of non-functioning protein crosslinks. The resulting accumulation of damaged proteins leads to senile ocular diseases. [7]
Applying Nutrients Directly to the Eyes:
Degenerative changes in the eye often begin in middle age, resulting in macular degeneration, glaucoma, cataracts and other forms of retinopathy in later life. Scientific studies indicate that the topical application of certain nutrients may help to prevent common senile eye disorders. In response to these published reports, an eye drop solution called Brite Eyes II™ has been developed that contains specially designed antioxidants, lubricants and
anti-glycating agents.
Brite Eyes II™ contains two lubricants (Carboxymethylcellulose and glycerin) approved by the FDA for ophthalmic use. These lubricants provide a synergistic effect in protecting against "dry eyes" and other forms of eye irritation. Additionally, Brite Eyes II™ contains potent concentrations of the following antioxidants:
L-Carnosine is a naturally occurring antioxidant and anti-glycation agent has shown remarkable effects that protect the eyes in published studies. Brite Eyes II™ contains 1% N-Acetyl- L-Carnosine, which acts as a time-release version of L-Carnosine. This form of carnosine has access to both the aqueous parts and lipid compartments of the eye. [9] After entering the lipid compartments of the eye, N-Acetyl-L-Carnosine degrades to L-Carnosine, thus protecting the lipid tissues of the eye from light damage. [8] A recent study showed that carnosine helped to prevent light-induced DNA strand breaks. Furthermore, carnosine application to the eye allowed significant repair of all DNA strands examined. [9] In Russia, carnosine eye drops are approved for corneal erosion, trophic keratitis, postherpetic epitheliopathy, primary and secondary corneal dystrophy, and bullous keratopathy. [10]
Brite Eyes II™ also contains the important antioxidants Vitamin A and Vitamin E. Many references show the importance of these vitamins in helping the aging eye. Vitamin A is essential for the health and function of epithelial cells. Topically applied Vitamin A has corrected many eye disorders and contact lens related problems with epithelial cells in the cornea, conjunctiva, and eyelids. A deficiency of Vitamin A in the eye can cause an abnormal tear film, leading to severe dry eyes and more discomfort for contact lens wearers. [17-29] Vitamin E is a powerful antioxidant and when used topically in the eye it can increase the survival time of corneal endothelial cells, decrease inflammation, speed up healing of eye tissues, regenerate glutathione in the eye, and even prevents cataracts in some animal studies. [11-16]
The Most Advanced Eye Formula:
Brite Eyes II™ offers protection above and beyond any other eye formula on the
market. The suggested use of Brite Eyes II™ is to apply 1-2 drops in each
eye every day. Those with any kind of eye problem may want to apply 1-2 drops
several times a day.
The 2 ml resealable tubes allow for a small amount of product to be exposed to
oxygen and bacteria at a time. The unopened tubes can be stored in the dark in
the refrigerator to extend shelf life.
Brite eyes II
ingredients
Active ingredients:
Glycerin (lubricant) 1.0% Carboxymethylcellulose sodium (lubricant) 0.3%
Inactive Ingredients:
Sterile water (ophthalmic grade isotonic solution, pH 6.3 to 6.5); antioxidants
N-Acetyl-Carnosine (NAC) 1.0%, vitamin A, vitamin E; buffered with borates and
potassium bicarbonate and as a preservative, purified benzyl alcohol.
Note: These statements have not been evaluated by the Food & Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
References:
1. Arch Ophthalmol 2000 Nov; 118(11): pp. 1556-1563, Int J Vitam Nutr Res 1999 May; 69(3): pp. 198-205
2. Ophthalmology 1996 Mar; 103(3): pp. 529-534
3. J Ocul Pharmacol Ther 2000 Apr; 16(2): pp. 121-135
4. Mol Vis 1999 Nov 3; 5:32
5. Prog Retin Eye Res 2000 Mar; 19(2): pp. 205-221
6. Arch Ophthalmol 2000 Aug; 118(8): pp. 1076-1080,Vestn Oftalmol 1999 Sep; 115(5): pp. 3-4
7. Curr Eye Res 2000 Jul; 21(1): pp. 543-549, Free Radic Biol Med 1987; 3(6): pp. 371-377
8. Mol. Biol. Part B: (2000), 127B; (4): pp. 443-446, Clin. Chim. Acta., 1996; 254(1): pp. 1-21
9. Photochemistry and Photobiology, (2000), 71; (5): pp. 559-566.
10. Biochemistry (Moscow)(2000), 65(5): pp. 588-598.
11. Ophthalmologica. 2001 May-Jun;215(3):192-6.
12. Aust N Z J Ophthalmol 1987 Nov;15(4):309-14
13. J Ocul Pharmacol Ther 1999 Aug;15(4):345-50
14. Exp Eye Res 1999 Jun;68(6):747-55
15. Ann Nutr Metab 1999;43(5):286-9
16. Klin Oczna 1998;100(2):85-8
17. Ophthalmology 1983; 90: 592-600.
18. Curr Eye Res 1985; 4: 1049-1057.
19. Curr Eye Res 1984; 3(6): 815-822.
20. So African Optom 1990; 49: 143.
21. Afro-Asian Journal of Ophthalmology 1988; 7(December): 74-83.
22. Ophthalmology 1988; 95: 1442-1446.
23. Fortschr Ophthalmol 1989; 86(5): 530-534.
24. Trans Ophthalmol Soc (UK) 1985; 104: 869-874.
25. Contact Lens Journal (UK) 1988; 16: 169-170.
26. International Contact Lens Clinic 1990; 17: 139-143.
27. Ophthalmology 1985; 92" 717-727.
28. Am J Ophthalmol 1983; 95: 349-352.
29. Contact Lens Journal (UK) 1991; 19: 165-173.
|
